"COVID-19 vaccine deployment faces an unprecedented degree of uncertainty and complexity, which is difficult to communicate, such as immune response, duration of immunity, repeated vaccination, transmission dynamics, microbiological and clinical characteristics and multiple vaccines. Priority groups for vaccine deployment need transparent public debate to build support for ethical principles. Current seasonal flu uptake is low in certain groups, suggesting vaccination challenges, which include: high risk groups under the age of 65 (40 - 50%), support staff in health care organisations (as low as 37%) and London and even variation amongst key workers such as Doctors (40 - 100%). Deployment and tracking should build on existing immunisation programmes such as primary care by GPs to identify comorbidities, track vaccinations and reminders for additional boosters. COVID-19 vaccine deployment faces an infodemic with misinformation often filling the knowledge void, characterised by: (1) distrust of science and selective use of expert authority, (2) distrust in pharmaceutical companies and government, (3) straightforward explanations, (4) use of emotion; and, (5) echo chambers. A narrow focus on misinformation disregards the fact that there are genuine knowledge voids, necessitating public dialogue about vaccine concerns and hesitancy rather than providing passive one-way communication strategies." (Summary of key points, page 1)